Changes between Version 3 and Version 4 of Applications


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Timestamp:
Oct 1, 2008, 11:13:01 AM (17 years ago)
Author:
regina_samaga@…
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  • Applications

    v3 v4  
    66'''Logical Modeling of growth factor signaling in hepatocytes'''
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    8 Using ProMoT, we built up a logical model of epidermal growth factor receptor signaling in hepatocytes. The model is currently extended by the hepatocyte growth factor signaling pathway; further pathways will be included in the near future. This project is part of the research initiative HepatoSys (funded by the German Federal Ministry of Education and Research, BMBF).
     8Using ProMoT, we built up a large-scale logical model of epidermal growth factor (EGF) receptor signaling in hepatocytes. The model comprises 106 species and 207 interactions describing signaling through the four different receptors of the EGF receptor family in response to 13 different ligands. The Erk/JNK/p38 MAPK pathways are included as well as PI3K signaling, the PLC gamma pathway and activation of STATs. The output layer is made up of different transcription factors and kinases that are important for proliferation, growth and survival.[[BR]]
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    10 To analyze the model, it is exported to the software tool [http://www.mpi-magdeburg.mpg.de/projects/cna/cna.html CellNetAnalyzer]. The results of the analysis in CellNetAnalyzer are imported in ProMoT, where they are visualized.
     10To analyze the model, it is exported to the software tool [http://www.mpi-magdeburg.mpg.de/projects/cna/cna.html CellNetAnalyzer]. The results of the analysis in !CellNetAnalyzer are again imported in ProMoT, where they are visualized.
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     12The model is currently extended by the hepatocyte growth factor signaling pathway; further pathways will be included in the near future. This project is part of the research initiative !HepatoSys (funded by the German Federal Ministry of Education and Research, BMBF).