(set-icon-path ("promot:kb;SignalTransd;structure;" "promot:kb;sbml;" "promot:kb;SignalTransd;libraries;")) (set-mdl-path ("promot:kb;sbml;" "promot:kb;SignalTransd;structure;")) (include "/afs/mpi-magdeburg.mpg.de/usr/local101/diana/promot/kb/dynamic_library/dynamic-library.mdl") (include "/afs/mpi-magdeburg.mpg.de/usr/local101/diana/promot/kb/sbml/sbml-library.mdl") (include "/afs/mpi-magdeburg.mpg.de/usr/local101/diana/promot/kb/dynamic_library/aux-reactions.mdl") ;;================Definitions==================== (define-module :class "s-2-1" :super-classes ("structure") :parameters (("e_p1" :relation "t_p1.r == gamma_p1*r") ("e_r1" :relation "t_r1.r == gamma_r1*r") ("e_r2" :relation "t_r2.r == gamma_r2*r") ("gamma_p1" :value "1.0d0") ("gamma_r1" :value "-1.0d0") ("gamma_r2" :value "-1.0d0")) :terminals (("t_p1" :is-a "tflux" :geometry-side "right" :geometry-position "0.5") ("t_r1" :is-a "tflux" :geometry-side "left" :geometry-position "0.33333334") ("t_r2" :is-a "tflux" :geometry-side "left" :geometry-position "0.6666667")) :variables (("gamma_p1" :is-a "stoichiometry") ("gamma_r1" :is-a "stoichiometry") ("gamma_r2" :is-a "stoichiometry")) :equations (("e_p1") ("e_r1") ("e_r2"))) (define-module :class "kin-2-1_0_1_k9f_k9b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k9b" :is-a "kinetic-parameter") ("k9f" :is-a "kinetic-parameter"))) (define-module :class "s-1-1" :super-classes ("structure") :parameters (("e_p1" :relation "t_p1.r == gamma_p1*r") ("e_r1" :relation "t_r1.r == gamma_r1*r") ("gamma_p1" :value "1.0d0") ("gamma_r1" :value "-1.0d0")) :terminals (("t_p1" :is-a "tflux" :geometry-side "right" :geometry-position "0.5") ("t_r1" :is-a "tflux" :geometry-side "left" :geometry-position "0.5")) :variables (("gamma_p1" :is-a "stoichiometry") ("gamma_r1" :is-a "stoichiometry")) :equations (("e_p1") ("e_r1"))) (define-module :class "kin-1-1_0_1_v8_k8" :super-classes ("s-1-1" "kinetics") :icon "icons/irrev_r" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k8" :is-a "kinetic-parameter") ("v8" :is-a "kinetic-parameter"))) (define-module :class "s-1-2" :super-classes ("structure") :parameters (("e_p1" :relation "t_p1.r == gamma_p1*r") ("e_p2" :relation "t_p2.r == gamma_p2*r") ("e_r1" :relation "t_r1.r == gamma_r1*r") ("gamma_p1" :value "1.0d0") ("gamma_p2" :value "1.0d0") ("gamma_r1" :value "-1.0d0")) :terminals (("t_p1" :is-a "tflux" :geometry-side "right" :geometry-position "0.33333334") ("t_p2" :is-a "tflux" :geometry-side "right" :geometry-position "0.6666667") ("t_r1" :is-a "tflux" :geometry-side "left" :geometry-position "0.5")) :variables (("gamma_p1" :is-a "stoichiometry") ("gamma_p2" :is-a "stoichiometry") ("gamma_r1" :is-a "stoichiometry")) :equations (("e_p1") ("e_p2") ("e_r1"))) (define-module :class "kin-1-2_0_1_k7f_k7b" :super-classes ("s-1-2" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k7b" :is-a "kinetic-parameter") ("k7f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_1_k6f_k6b" :super-classes ("s-1-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k6b" :is-a "kinetic-parameter") ("k6f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k5f_k5b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k5b" :is-a "kinetic-parameter") ("k5f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_1_v4_k4" :super-classes ("s-1-1" "kinetics") :icon "icons/irrev_r" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k4" :is-a "kinetic-parameter") ("v4" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_1_k3f_k3b" :super-classes ("s-1-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k3b" :is-a "kinetic-parameter") ("k3f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_1_k25f_k25b" :super-classes ("s-1-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k25b" :is-a "kinetic-parameter") ("k25f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k24f_k24b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k24b" :is-a "kinetic-parameter") ("k24f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_1_k23f_k23b" :super-classes ("s-1-2" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k23b" :is-a "kinetic-parameter") ("k23f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k22f_k22b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k22b" :is-a "kinetic-parameter") ("k22f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k21f_k21b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k21b" :is-a "kinetic-parameter") ("k21f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_1_k20f_k20b" :super-classes ("s-1-2" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k20b" :is-a "kinetic-parameter") ("k20f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_1_k2f_k2b" :super-classes ("s-1-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k2b" :is-a "kinetic-parameter") ("k2f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k19f_k19b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k19b" :is-a "kinetic-parameter") ("k19f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_1_k18f_k18b" :super-classes ("s-1-2" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k18b" :is-a "kinetic-parameter") ("k18f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k17f_k17b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k17b" :is-a "kinetic-parameter") ("k17f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_1_v16_k16" :super-classes ("s-1-1" "kinetics") :icon "icons/irrev_r" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k16" :is-a "kinetic-parameter") ("v16" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_1_k15f_k15b" :super-classes ("s-1-2" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k15b" :is-a "kinetic-parameter") ("k15f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_1_k14f_k14b" :super-classes ("s-1-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k14b" :is-a "kinetic-parameter") ("k14f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k13f_k13b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k13b" :is-a "kinetic-parameter") ("k13f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_1_k12f_k12b" :super-classes ("s-1-2" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k12b" :is-a "kinetic-parameter") ("k12f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_1_k11f_k11b" :super-classes ("s-1-2" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k11b" :is-a "kinetic-parameter") ("k11f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k10f_k10b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k10b" :is-a "kinetic-parameter") ("k10f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_1_k1f_k1b" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l" :terminals (("t_c1" :is-a "tvol" :geometry-side "bottom" :geometry-position "0.5")) :variables (("k1b" :is-a "kinetic-parameter") ("k1f" :is-a "kinetic-parameter"))) (define-module :class "kholodenko1999_egfrsignaling-compartment" :super-classes ("compartment") :rdf-annotation ((:name "BQB_IS" :resources ("urn:miriam:obo.go:GO%3A0005737"))) :geometry-width "1065" :geometry-height "1046" :parameters (("egf.c" :label "Epidermal_Growth_Factor" :model-name "EGF") ("egf.n" :value "680.0d0*v") ("fl_egf" :terminals ("egf.cf" "v1.t_r2")) ("fl_grb" :terminals ("grb.cf" "v9.t_r1" "v12.t_p1" "v17.t_r2" "v21.t_r1")) ("fl_gs" :terminals ("gs.cf" "v11.t_p1" "v12.t_r1" "v23.t_p1" "v24.t_r2")) ("fl_plcg" :terminals ("plcg.cf" "v5.t_r2" "v8.t_p1")) ("fl_plcgl" :terminals ("plcgl.cf" "v25.t_p1")) ("fl_plcgp" :terminals ("plcgp.cf" "v7.t_p1" "v8.t_r1" "v25.t_r1")) ("fl_r" :terminals ("r.cf" "v1.t_r1")) ("fl_r2" :terminals ("r2.cf" "v2.t_p1" "v3.t_r1" "v4.t_p1")) ("fl_ra" :terminals ("ra.cf" "v1.t_p1" "v2.t_r1")) ("fl_rg" :terminals ("rg.cf" "v9.t_p1" "v10.t_r1")) ("fl_rgs" :terminals ("rgs.cf" "v10.t_p1" "v11.t_r1")) ("fl_rp" :terminals ("rp.cf" "v3.t_p1" "v4.t_r1" "v5.t_r1" "v7.t_p2" "v9.t_r2" "v11.t_p2" "v13.t_r2" "v15.t_p1" "v18.t_p2" "v20.t_p2")) ("fl_rplcg" :terminals ("rplcg.cf" "v5.t_p1" "v6.t_r1")) ("fl_rplcgp" :terminals ("rplcgp.cf" "v6.t_p1" "v7.t_r1")) ("fl_rsh" :terminals ("rsh.cf" "v13.t_p1" "v14.t_r1")) ("fl_rshg" :terminals ("rshg.cf" "v17.t_p1" "v18.t_r1" "v19.t_r2")) ("fl_rshgs" :terminals ("rshgs.cf" "v19.t_p1" "v20.t_r1" "v24.t_p1")) ("fl_rshp" :terminals ("rshp.cf" "v14.t_p1" "v15.t_r1" "v17.t_r1" "v24.t_r1")) ("fl_shg" :terminals ("shg.cf" "v18.t_p1" "v21.t_p1" "v22.t_r1")) ("fl_shgs" :terminals ("shgs.cf" "v20.t_p1" "v22.t_p1" "v23.t_r1")) ("fl_sos" :terminals ("sos.cf" "v10.t_r2" "v12.t_p2" "v19.t_r1" "v22.t_r2")) ("grb.c" :label "Grb2" :model-name "Grb") ("grb.n" :value "85.0d0*v") ("gs.c" :label "Grb2_SOS" :model-name "GS") ("gs.n" :value "0.0d0") ("plcg.c" :label "PLCg" :model-name "PLCg") ("plcg.n" :value "105.0d0*v") ("plcgl.c" :label "PLCgP-I" :model-name "PLCgl") ("plcgl.n" :value "0.0d0") ("plcgp.c" :label "PLCg-P" :model-name "PLCgP") ("plcgp.n" :value "0.0d0") ("r.c" :label "EGFR" :model-name "R") ("r.n" :value "100.0d0*v") ("r2.c" :label "(EGF_EGFR)2" :model-name "R2") ("r2.n" :value "0.0d0") ("ra.c" :label "EGF_EGFR" :model-name "Ra") ("ra.n" :value "0.0d0") ("rg.c" :label "(EGF_EGFR)2_Grb2" :model-name "RG") ("rg.n" :value "0.0d0") ("rgs.c" :label "(EGF_EGFR)2_Grb2_SOS" :model-name "RGS") ("rgs.n" :value "0.0d0") ("rp.c" :label "(EGF_EGFR)2-P" :model-name "RP") ("rp.n" :value "0.0d0") ("rplcg.c" :label "(EGF_EGFR)2_PLCg" :model-name "RPLCg") ("rplcg.n" :value "0.0d0") ("rplcgp.c" :label "(EGF_EGFR)2_PLCg-P" :model-name "RPLCgP") ("rplcgp.n" :value "0.0d0") ("rsh.c" :label "(EGF_EGFR)2_Shc" :model-name "RSh") ("rsh.n" :value "0.0d0") ("rshg.c" :label "(EGF_EGFR)2_Shc_Grb2" :model-name "RShG") ("rshg.n" :value "0.0d0") ("rshgs.c" :label "(EGF_EGFR)2_Shc_Grb2_SOS" :model-name "RShGS") ("rshgs.n" :value "0.0d0") ("rshp.c" :label "(EGF_EGFR)_Shc-P" :model-name "RShP") ("rshp.n" :value "0.0d0") ("shc_0_0.c" :label "Shc" :model-name "Shc") ("shc_0_0.n" :value "150.0d0*v") ("shc_0_0cf_v13t_r1" :terminals ("shc_0_0.cf" "v13.t_r1" "v16.t_p1")) ("shc_0_p.c" :label "Shc-P" :model-name "ShP") ("shc_0_p.n" :value "0.0d0") ("shc_0_pcf_v15t_p2" :terminals ("shc_0_p.cf" "v15.t_p2" "v16.t_r1" "v21.t_r2" "v23.t_p2")) ("shg.c" :label "Shc_Grb2" :model-name "ShG") ("shg.n" :value "0.0d0") ("shgs.c" :label "Shc_Grb2_SOS" :model-name "ShGS") ("shgs.n" :value "0.0d0") ("sos.c" :label "SOS" :model-name "SOS") ("sos.n" :value "34.0d0*v") ("v" :label "cytoplasm" :value "3.0d-12" :model-name "compartment") ("v1.k1b" :value "0.06d0") ("v1.k1f" :value "0.003d0") ("v1.r" :label "EGF_binds_to_EGFR" :value "(k1f*t_r1.c*t_r2.c-k1b*t_p1.c)*t_c1.v" :model-name "v1") ("v10.k10b" :value "0.06d0") ("v10.k10f" :value "0.01d0") ("v10.r" :label "binding_of_SOS_to_RG" :value "(k10f*t_r1.c*t_r2.c-k10b*t_p1.c)*t_c1.v" :model-name "v10") ("v11.k11b" :value "0.0045d0") ("v11.k11f" :value "0.03d0") ("v11.r" :label "dissociation_of_RGS" :value "(k11f*t_r1.c-k11b*t_p2.c*t_p1.c)*t_c1.v" :model-name "v11") ("v12.k12b" :value "1.0d-4") ("v12.k12f" :value "0.0015d0") ("v12.r" :label "dissociation_of_GS" :value "(k12f*t_r1.c-k12b*t_p1.c*t_p2.c)*t_c1.v" :model-name "v12") ("v13.k13b" :value "0.6d0") ("v13.k13f" :value "0.09d0") ("v13.r" :label "binding_of_Shc_to_RP" :value "(k13f*t_r2.c*t_r1.c-k13b*t_p1.c)*t_c1.v" :model-name "v13") ("v14.k14b" :value "0.06d0") ("v14.k14f" :value "6.0d0") ("v14.r" :label "phosphorylation_of_RSh" :value "(k14f*t_r1.c-k14b*t_p1.c)*t_c1.v" :model-name "v14") ("v15.k15b" :value "9.0d-4") ("v15.k15f" :value "0.3d0") ("v15.r" :label "dissociation_of_RShp" :value "(k15f*t_r1.c-k15b*t_p2.c*t_p1.c)*t_c1.v" :model-name "v15") ("v16.k16" :value "340.0d0") ("v16.r" :label "dephosphorylation_of_ShP" :value "v16*t_r1.c/(k16+t_r1.c)*t_c1.v" :model-name "v16") ("v16.reversible" :value "0") ("v16.v16" :value "1.7d0") ("v17.k17b" :value "0.1d0") ("v17.k17f" :value "0.003d0") ("v17.r" :label "binding_of_Grb2_to_RShP" :value "(k17f*t_r1.c*t_r2.c-k17b*t_p1.c)*t_c1.v" :model-name "v17") ("v18.k18b" :value "9.0d-4") ("v18.k18f" :value "0.3d0") ("v18.r" :label "dissociation_of_RShG" :value "(k18f*t_r1.c-k18b*t_p2.c*t_p1.c)*t_c1.v" :model-name "v18") ("v19.k19b" :value "0.0214d0") ("v19.k19f" :value "0.01d0") ("v19.r" :label "binding_of_SOS_to_RShG" :value "(k19f*t_r2.c*t_r1.c-k19b*t_p1.c)*t_c1.v" :model-name "v19") ("v2.gamma_r1" :value "-2.0d0") ("v2.k2b" :value "0.1d0") ("v2.k2f" :value "0.01d0") ("v2.r" :label "association_of_2_Ra_into_dimer" :value "(k2f*t_r1.c*t_r1.c-k2b*t_p1.c)*t_c1.v" :model-name "v2") ("v20.k20b" :value "2.4d-4") ("v20.k20f" :value "0.12d0") ("v20.r" :label "dissociation_of_RShGS" :value "(k20f*t_r1.c-k20b*t_p1.c*t_p2.c)*t_c1.v" :model-name "v20") ("v21.k21b" :value "0.1d0") ("v21.k21f" :value "0.003d0") ("v21.r" :label "binding_of_Grb2_to_ShP" :value "(k21f*t_r2.c*t_r1.c-k21b*t_p1.c)*t_c1.v" :model-name "v21") ("v22.k22b" :value "0.064d0") ("v22.k22f" :value "0.03d0") ("v22.r" :label "binding_of_SOS_to_ShG" :value "(k22f*t_r1.c*t_r2.c-k22b*t_p1.c)*t_c1.v" :model-name "v22") ("v23.k23b" :value "0.021d0") ("v23.k23f" :value "0.1d0") ("v23.r" :label "dissociation_of_ShGS" :value "(k23f*t_r1.c-k23b*t_p2.c*t_p1.c)*t_c1.v" :model-name "v23") ("v24.k24b" :value "0.0429d0") ("v24.k24f" :value "0.009d0") ("v24.r" :label "association_of_RShP_and_GS" :value "(k24f*t_r1.c*t_r2.c-k24b*t_p1.c)*t_c1.v" :model-name "v24") ("v25.k25b" :value "0.03d0") ("v25.k25f" :value "1.0d0") ("v25.r" :label "translocation_of_PLCgP" :value "(k25f*t_r1.c-k25b*t_p1.c)*t_c1.v" :model-name "v25") ("v3.k3b" :value "0.01d0") ("v3.k3f" :value "1.0d0") ("v3.r" :label "phosphorylation_of_R2" :value "(k3f*t_r1.c-k3b*t_p1.c)*t_c1.v" :model-name "v3") ("v4.k4" :value "50.0d0") ("v4.r" 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"581") ("v6" :is-a "kin-1-1_0_1_k6f_k6b" :geometry-x "792" :geometry-y "523") ("v7" :is-a "kin-1-2_0_1_k7f_k7b" :geometry-x "678" :geometry-y "574") ("v8" :is-a "kin-1-1_0_1_v8_k8" :geometry-x "736" :geometry-y "665") ("v9" :is-a "kin-2-1_0_1_k9f_k9b" :geometry-x "451" :geometry-y "607") ("va" :is-a "adapter-volume-pop" :geometry-x "582" :geometry-y "593")) :links (("fl_egf") ("fl_grb" :nodes (("243" "507")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil) ("4" "-1" nil))) ("fl_gs" :nodes (("306" "430")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil) ("4" "-1" nil))) ("fl_plcg" :nodes (("827" "669")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil))) ("fl_plcgl") ("fl_plcgp" :nodes (("755" "719")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil))) ("fl_r") ("fl_r2" :nodes (("670" "358")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil))) ("fl_ra" :nodes (("733" "165")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil))) ("fl_rg" :nodes (("497" "757")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil))) ("fl_rgs" :nodes (("543" "723")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil))) ("fl_rp" :nodes (("549" "537")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil) ("4" "-1" nil) ("5" "-1" nil) ("6" "-1" nil) ("7" "-1" nil) ("8" "-1" nil) ("9" "-1" nil) ("10" "-1" nil))) ("fl_rplcg" :nodes (("860" "563")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil))) ("fl_rplcgp" :nodes (("846" "489")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil))) ("fl_rsh" :nodes (("383" "849")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil))) ("fl_rshg" :nodes (("288" "526")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil))) ("fl_rshgs" :nodes (("450" "375")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil))) ("fl_rshp" :nodes (("293" "644")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil) ("4" "-1" nil))) ("fl_shg" :nodes (("304" "327")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil))) ("fl_shgs" :nodes (("408" "282")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil))) ("fl_sos" :nodes (("372" "415")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil) ("4" "-1" nil))) ("shc_0_0cf_v13t_r1" :nodes (("298" "811")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil))) ("shc_0_pcf_v15t_p2" :nodes (("231" "555")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil) ("4" "-1" nil))) ("vl_compartment" :nodes (("501" "543")) :edges (("0" "-1" nil) ("1" "-1" nil) ("2" "-1" nil) ("3" "-1" nil) ("4" "-1" nil) ("5" "-1" nil) ("6" "-1" nil) ("7" "-1" nil) ("8" "-1" nil) ("9" "-1" nil) ("10" "-1" nil) ("11" "-1" nil) ("12" "-1" nil) ("13" "-1" nil) ("14" "-1" nil) ("15" "-1" nil) ("16" "-1" nil) ("17" "-1" nil) ("18" "-1" nil) ("19" "-1" nil) ("20" "-1" nil) ("21" "-1" nil) ("22" "-1" nil) ("23" "-1" nil) ("24" "-1" nil) ("25" "-1" nil))))) (define-module :class "kholodenko1999_egfrsignaling" :super-classes ("sbml-model") :documentation "

SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS

Run this model online at http://jjj.biochem.sun.ac.za

To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online, Bioinformatics, 20:2143-2144

The model correctly reproduces all the figures from the paper. The curation has been done using SBMLodeSolver.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.

For more information see the terms of use.

To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

" :rdf-annotation ((:name "BQM_IS" :resources ("urn:miriam:biomodels.db:BIOMD0000000048")) (:name "BQM_IS_DESCRIBED_BY" :resources ("urn:miriam:pubmed:10514507")) (:name "BQB_IS" :resources ("urn:miriam:taxonomy:10116" "urn:miriam:obo.go:GO%3A0007173"))) :geometry-width "333" :geometry-height "347" :modules (("compartment" :is-a "kholodenko1999_egfrsignaling-compartment" :geometry-x "161" :geometry-y "177"))) (define-module :class "kin-1-1_2" :super-classes ("s-1-1" "kinetics") :icon "icons/rev_l" :terminals (("t_m1" :is-a "tsig" :geometry-side "top" :geometry-position "0.33333334") ("t_m2" :is-a "tsig" :geometry-side "top" :geometry-position "0.6666667"))) (define-module :class "kin-2-1_0" :super-classes ("s-2-1" "kinetics") :icon "icons/rev_l") (define-module :class "insulin_reduced2_xml-cell" :super-classes ("compartment") :rdf-annotation ((:name "BQB_IS" :resources ("urn:miriam:obo.go:GO%3A0005737"))) :geometry-width "1739" :geometry-height "1870" :parameters (("cl_xirsgrb2" 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("rxpshc" :relation "0.0d0 == t_rxpshc.c-t_xrshc.c+t_xrshcb.c") ("r_x_p_x" :relation "0.0d0 == t_r_x_p_x.c-t_r_0_p_0.c-t_r_0_p_p.c-t_r_i_p_0.c-t_r_i_p_p.c") ("r_x_x_p" :relation "0.0d0 == t_r_x_x_p.c-t_r_0_0_p.c-t_r_0_p_p.c-t_r_i_0_p.c-t_r_i_p_p.c") ("shcxp" :relation "0.0d0 == t_shcxp.c-t_xshc.c+t_xshcb.c") ("shc_r_x" :relation "0.0d0 == t_shc_r_x.c-t_shc_r_0.c-t_shc_r_p.c") ("shc_x_p" :relation "0.0d0 == t_shc_x_p.c-t_shc_0_p.c-t_shc_r_p.c") ("xirsgrb2" :relation "0.0d0 == t_xirsgrb2.c-t_irs_x_p.c") ("xirsgrb2b" :relation "0.0d0 == t_xirsgrb2b.c-t_grb2_irs_x.c") ("xrirs" :relation "0.0d0 == t_xrirs.c-2*t_r_x_x_p.c") ("xrirsb" :relation "0.0d0 == t_xrirsb.c-t_irs_r_x.c") ("xrshc" :relation "0.0d0 == t_xrshc.c-2*t_r_x_p_x.c") ("xrshcb" :relation "0.0d0 == t_xrshcb.c-t_shc_r_x.c") ("xshc" :relation "0.0d0 == t_xshc.c-t_shc_x_p.c") ("xshcb" :relation "0.0d0 == t_xshcb.c-t_grb2_shc_x.c")) :terminals (("t_grb2_irs_0" :is-a "tsig" :geometry-side "top" :geometry-position "0.05263158") ("t_grb2_irs_sos" :is-a "tsig" :geometry-side "top" :geometry-position "0.078947365") ("t_grb2_irs_x" :is-a "tsig" :geometry-side "top" :geometry-position "0.10526316") ("t_grb2_shc_0" :is-a "tsig" :geometry-side "top" :geometry-position "0.13157895") ("t_grb2_shc_sos" :is-a "tsig" :geometry-side "top" :geometry-position "0.15789473") ("t_grb2_shc_x" :is-a "tsig" :geometry-side "top" :geometry-position "0.18421052") ("t_ins" :is-a "tsig" :geometry-side "top" :geometry-position "0.02631579") ("t_irsxpgrb2" :is-a "tsig" :geometry-side "top" :geometry-position "0.92105263") ("t_irs_0_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.28947368") ("t_irs_r_0" :is-a "tsig" :geometry-side "top" :geometry-position "0.21052632") ("t_irs_r_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.23684211") ("t_irs_r_x" :is-a "tsig" :geometry-side "top" :geometry-position "0.2631579") ("t_irs_x_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.31578946") ("t_rxpirs" :is-a "tsig" :geometry-side "top" :geometry-position "0.7631579") ("t_rxpshc" :is-a "tsig" :geometry-side "top" :geometry-position "0.84210527") ("t_r_0_0_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.47368422") ("t_r_0_p_0" :is-a "tsig" :geometry-side "top" :geometry-position "0.34210527") ("t_r_0_p_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.36842105") ("t_r_i_0_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.5") ("t_r_i_p_0" :is-a "tsig" :geometry-side "top" :geometry-position "0.39473686") ("t_r_i_p_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.42105263") ("t_r_x_p_x" :is-a "tsig" :geometry-side "top" :geometry-position "0.4473684") ("t_r_x_x_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.5263158") ("t_shcxp" :is-a "tsig" :geometry-side "top" :geometry-position "0.9736842") ("t_shc_0_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.6315789") ("t_shc_r_0" :is-a "tsig" :geometry-side "top" :geometry-position "0.55263156") ("t_shc_r_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.57894737") ("t_shc_r_x" :is-a "tsig" :geometry-side "top" :geometry-position "0.6052632") ("t_shc_x_p" :is-a "tsig" :geometry-side "top" :geometry-position "0.65789473") ("t_xirsgrb2" :is-a "tsig" :geometry-side "top" :geometry-position "0.7894737") ("t_xirsgrb2b" :is-a "tsig" :geometry-side "top" :geometry-position "0.8947368") ("t_xrirs" :is-a "tsig" :geometry-side "top" :geometry-position "0.68421054") ("t_xrirsb" :is-a "tsig" :geometry-side "top" :geometry-position "0.7368421") ("t_xrshc" :is-a "tsig" :geometry-side "top" :geometry-position "0.7105263") ("t_xrshcb" :is-a "tsig" :geometry-side "top" :geometry-position "0.81578946") ("t_xshc" :is-a "tsig" :geometry-side "top" :geometry-position "0.8684211") ("t_xshcb" :is-a "tsig" :geometry-side "top" :geometry-position "0.94736844")) :equations (("grb2_irs_x") ("grb2_shc_x") ("ins") ("irsxpgrb2") ("irs_r_x") ("irs_x_p") ("rxpirs") ("rxpshc") ("r_x_p_x") ("r_x_x_p") ("shcxp") ("shc_r_x") ("shc_x_p") ("xirsgrb2") ("xirsgrb2b") ("xrirs") ("xrirsb") ("xrshc") ("xrshcb") ("xshc") ("xshcb"))) (define-module :class "insulin_reduced2_xml" :super-classes ("sbml-model") :documentation "

This model was generated Mon May 10 16:18:40 2010

reaction_0: R[0,0,0]+Ins{-}R[I,0,0] ki1 ki1d

reaction_1: R[0,0,P]+Ins{-}R[I,0,P] ki1 ki1d

reaction_2: R[0,P,0]+Ins{-}R[I,P,0] ki1 ki1d

reaction_3: R[0,P,P]+Ins{-}R[I,P,P] ki1 ki1d

reaction_4: R[0,0,0]{-}R[0,P,0] kp10 kp10d

reaction_5: R[0,0,P]{-}R[0,P,P] kp10 kp10d

reaction_6: R[I,0,0]{-}R[I,P,0] kp11 kp11d

reaction_7: R[I,0,P]{-}R[I,P,P] kp11 kp11d

reaction_8: R[0,0,0]{-}R[0,0,P] kp20 kp20d

reaction_9: R[0,P,0]{-}R[0,P,P] kp20 kp20d

reaction_10: R[I,0,0]{-}R[I,0,P] kp21 kp21d

reaction_11: R[I,P,0]{-}R[I,P,P] kp21 kp21d

reaction_12: RXpIrs+IRS[0,0]{-}IRS[R,0] kbirs kbirsd

reaction_13: RXpIrs+IRS[0,P]{-}IRS[R,P] kbirs kbirsd

reaction_14: IRS[0,0]{-}IRS[0,P] kirsp6 kirsp6d

reaction_15: IRS[R,0]{-}IRS[R,P] kirsbp6 kirsbp6d

reaction_16: RXpShc+Shc[0,0]{-}Shc[R,0] kbshc kbshcd

reaction_17: RXpShc+Shc[0,P]{-}Shc[R,P] kbshc kbshcd

reaction_18: Shc[0,0]{-}Shc[0,P] kshcp kshcpd

reaction_19: Shc[R,0]{-}Shc[R,P] kshcbp kshcbpd

reaction_20: IrsXpGrb2+Grb2[0,0]{-}Grb2[IRS,0] kbirsgrb2 kbirsgrb2d

reaction_21: IrsXpGrb2+Grb2[0,SOS]{-}Grb2[IRS,SOS] kbirsgrb2sos kbirsgrb2sosd

reaction_22: Grb2[0,0]+SOS{-}Grb2[0,SOS] kbsos kbsosd

reaction_23: Grb2[IRS,0]+SOS{-}Grb2[IRS,SOS] kbsos kbsosd

reaction_24: Grb2[Shc,0]+SOS{-}Grb2[Shc,SOS] kbsos kbsosd

reaction_25: ShcXp+Grb2[0,0]{-}Grb2[Shc,0] kbshcgrb2 kbshcgrb2d

reaction_26: ShcXp+Grb2[0,SOS]{-}Grb2[Shc,SOS] kbshcgrb2sos kbshcgrb2sosd

" :geometry-width "801" :geometry-height "515" :parameters (("cl_grb2_irs_0" :terminals ("ca_grb2_irs_0.co" "rules.t_grb2_irs_0")) ("cl_grb2_irs_sos" :terminals ("ca_grb2_irs_sos.co" "rules.t_grb2_irs_sos")) ("cl_grb2_irs_x" :terminals ("ca_grb2_irs_x.co" "rules.t_grb2_irs_x")) ("cl_grb2_shc_0" :terminals ("ca_grb2_shc_0.co" "rules.t_grb2_shc_0")) ("cl_grb2_shc_sos" :terminals ("ca_grb2_shc_sos.co" "rules.t_grb2_shc_sos")) ("cl_grb2_shc_x" :terminals ("ca_grb2_shc_x.co" "rules.t_grb2_shc_x")) ("cl_ins" :terminals ("ca_ins.co" "rules.t_ins")) ("cl_irsxpgrb2" :terminals ("ca_irsxpgrb2.co" "rules.t_irsxpgrb2")) ("cl_irs_0_p" :terminals ("ca_irs_0_p.co" "rules.t_irs_0_p")) ("cl_irs_r_0" :terminals ("ca_irs_r_0.co" "rules.t_irs_r_0")) ("cl_irs_r_p" :terminals ("ca_irs_r_p.co" "rules.t_irs_r_p")) ("cl_irs_r_x" :terminals ("ca_irs_r_x.co" "rules.t_irs_r_x")) ("cl_irs_x_p" :terminals ("ca_irs_x_p.co" "rules.t_irs_x_p")) ("cl_rxpirs" :terminals ("ca_rxpirs.co" "rules.t_rxpirs")) ("cl_rxpshc" 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:system-theoretic "real-parameter" :value "1.0d0" :model-name "kbsos") ("kbsosd" :label "kbsosd" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kbsosd") ("ki1" :label "ki1" :system-theoretic "real-parameter" :value "1.0d0" :model-name "ki1") ("ki1d" :label "ki1d" :system-theoretic "real-parameter" :value "1.0d0" :model-name "ki1d") ("kirsbp6" :label "kirsbp6" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kirsbp6") ("kirsbp6d" :label "kirsbp6d" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kirsbp6d") ("kirsp6" :label "kirsp6" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kirsp6") ("kirsp6d" :label "kirsp6d" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kirsp6d") ("kp10" :label "kp10" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kp10") ("kp10d" :label "kp10d" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kp10d") ("kp11" :label "kp11" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kp11") ("kp11d" :label "kp11d" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kp11d") ("kp20" :label "kp20" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kp20") ("kp20d" :label "kp20d" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kp20d") ("kp21" :label "kp21" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kp21") ("kp21d" :label "kp21d" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kp21d") ("kshcbp" :label "kshcbp" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kshcbp") ("kshcbpd" :label "kshcbpd" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kshcbpd") ("kshcp" :label "kshcp" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kshcp") ("kshcpd" :label "kshcpd" :system-theoretic "real-parameter" :value "1.0d0" :model-name "kshcpd")) :modules (("ca_grb2_irs_0" :is-a "cf2co" :geometry-x "148" :geometry-y "223") ("ca_grb2_irs_sos" :is-a "cf2co" :geometry-x "140" :geometry-y "265") ("ca_grb2_irs_x" :is-a "cf2co" :geometry-x "147" :geometry-y "381") ("ca_grb2_shc_0" :is-a "cf2co" :geometry-x "177" :geometry-y "253") ("ca_grb2_shc_sos" :is-a "cf2co" :geometry-x "210" :geometry-y "229") ("ca_grb2_shc_x" :is-a "cf2co" :geometry-x "205" :geometry-y "414") ("ca_ins" :is-a "cf2co" :geometry-x "110" :geometry-y "260") ("ca_irsxpgrb2" :is-a "cf2co" :geometry-x "629" :geometry-y "211") ("ca_irs_0_p" :is-a "cf2co" :geometry-x "266" :geometry-y "220") ("ca_irs_r_0" :is-a "cf2co" :geometry-x "215" :geometry-y "259") ("ca_irs_r_p" :is-a "cf2co" :geometry-x "225" :geometry-y "243") ("ca_irs_r_x" :is-a "cf2co" :geometry-x "260" :geometry-y "389") ("ca_irs_x_p" :is-a "cf2co" :geometry-x "298" :geometry-y "176") ("ca_rxpirs" :is-a "cf2co" :geometry-x "548" :geometry-y "202") ("ca_rxpshc" :is-a "cf2co" :geometry-x "578" :geometry-y "269") ("ca_r_0_0_p" :is-a "cf2co" :geometry-x "373" :geometry-y "204") ("ca_r_0_p_0" :is-a "cf2co" :geometry-x "303" :geometry-y "248") ("ca_r_0_p_p" :is-a "cf2co" :geometry-x "324" :geometry-y "228") ("ca_r_i_0_p" :is-a "cf2co" :geometry-x "373" :geometry-y "433") ("ca_r_i_p_0" :is-a "cf2co" :geometry-x "313" :geometry-y "420") ("ca_r_i_p_p" :is-a "cf2co" :geometry-x "353" :geometry-y "306") ("ca_r_x_p_x" :is-a "cf2co" :geometry-x "342" :geometry-y "266") ("ca_r_x_x_p" :is-a "cf2co" :geometry-x "420" :geometry-y "418") ("ca_shcxp" :is-a "cf2co" :geometry-x "670" :geometry-y "248") ("ca_shc_0_p" :is-a "cf2co" :geometry-x "447" :geometry-y "210") ("ca_shc_r_0" :is-a "cf2co" :geometry-x "428" :geometry-y "369") ("ca_shc_r_p" :is-a "cf2co" :geometry-x "420" :geometry-y "198") ("ca_shc_r_x" :is-a "cf2co" :geometry-x "465" :geometry-y "256") ("ca_shc_x_p" :is-a "cf2co" :geometry-x "463" :geometry-y "187") ("ca_xirsgrb2" :is-a "cf2co" :geometry-x "533" :geometry-y "314") ("ca_xirsgrb2b" :is-a "cf2co" :geometry-x "628" :geometry-y "249") ("ca_xrirs" :is-a "cf2co" :geometry-x "503" :geometry-y "264") ("ca_xrirsb" :is-a "cf2co" :geometry-x "521" :geometry-y "241") ("ca_xrshc" :is-a "cf2co" :geometry-x "501" :geometry-y "170") ("ca_xrshcb" :is-a "cf2co" :geometry-x "542" :geometry-y "412") ("ca_xshc" :is-a "cf2co" :geometry-x "593" :geometry-y "329") ("ca_xshcb" :is-a "cf2co" :geometry-x "660" :geometry-y "264") ("cell" :is-a "insulin_reduced2_xml-cell" :geometry-x "419" :geometry-y "260") ("rules" :is-a "insulin_reduced2_xml-rules" :geometry-x "392" :geometry-y "291")) :links (("cl_grb2_irs_0") ("cl_grb2_irs_sos") ("cl_grb2_irs_x") ("cl_grb2_shc_0") ("cl_grb2_shc_sos") ("cl_grb2_shc_x") ("cl_ins") ("cl_irsxpgrb2") ("cl_irs_0_p") ("cl_irs_r_0") ("cl_irs_r_p") ("cl_irs_r_x") ("cl_irs_x_p") ("cl_rxpirs") ("cl_rxpshc") ("cl_r_0_0_p") ("cl_r_0_p_0") ("cl_r_0_p_p") ("cl_r_i_0_p") ("cl_r_i_p_0") ("cl_r_i_p_p") ("cl_r_x_p_x") ("cl_r_x_x_p") ("cl_shcxp") ("cl_shc_0_p") ("cl_shc_r_0") ("cl_shc_r_p") ("cl_shc_r_x") ("cl_shc_x_p") ("cl_xirsgrb2") ("cl_xirsgrb2b") ("cl_xrirs") ("cl_xrirsb") ("cl_xrshc") ("cl_xrshcb") ("cl_xshc") ("cl_xshcb") ("fl_grb2_irs_0") ("fl_grb2_irs_sos") ("fl_grb2_irs_x") ("fl_grb2_shc_0") ("fl_grb2_shc_sos") ("fl_grb2_shc_x") ("fl_ins") ("fl_irsxpgrb2") ("fl_irs_0_p") ("fl_irs_r_0") ("fl_irs_r_p") ("fl_irs_r_x") ("fl_irs_x_p") ("fl_rxpirs") ("fl_rxpshc") ("fl_r_0_0_p") ("fl_r_0_p_0") ("fl_r_0_p_p") ("fl_r_i_0_p") ("fl_r_i_p_0") ("fl_r_i_p_p") ("fl_r_x_p_x") ("fl_r_x_x_p") ("fl_shcxp") ("fl_shc_0_p") ("fl_shc_r_0") ("fl_shc_r_p") ("fl_shc_r_x") ("fl_shc_x_p") ("fl_xirsgrb2") ("fl_xirsgrb2b") ("fl_xrirs") ("fl_xrirsb") ("fl_xrshc") ("fl_xrshcb") ("fl_xshc") ("fl_xshcb")) :variables (("kbirs" :is-a "sbml-parameter") ("kbirsd" :is-a "sbml-parameter") ("kbirsgrb2" :is-a "sbml-parameter") ("kbirsgrb2d" :is-a "sbml-parameter") ("kbirsgrb2sos" :is-a "sbml-parameter") ("kbirsgrb2sosd" :is-a "sbml-parameter") ("kbshc" :is-a "sbml-parameter") ("kbshcd" :is-a "sbml-parameter") ("kbshcgrb2" :is-a "sbml-parameter") ("kbshcgrb2d" :is-a "sbml-parameter") ("kbshcgrb2sos" :is-a "sbml-parameter") ("kbshcgrb2sosd" :is-a "sbml-parameter") ("kbsos" :is-a "sbml-parameter") ("kbsosd" :is-a "sbml-parameter") ("ki1" :is-a "sbml-parameter") ("ki1d" :is-a "sbml-parameter") ("kirsbp6" :is-a "sbml-parameter") ("kirsbp6d" :is-a "sbml-parameter") ("kirsp6" :is-a "sbml-parameter") ("kirsp6d" :is-a "sbml-parameter") ("kp10" :is-a "sbml-parameter") ("kp10d" :is-a "sbml-parameter") ("kp11" :is-a "sbml-parameter") ("kp11d" :is-a "sbml-parameter") ("kp20" :is-a "sbml-parameter") ("kp20d" :is-a "sbml-parameter") ("kp21" :is-a "sbml-parameter") ("kp21d" :is-a "sbml-parameter") ("kshcbp" :is-a "sbml-parameter") ("kshcbpd" :is-a "sbml-parameter") ("kshcp" :is-a "sbml-parameter") ("kshcpd" :is-a "sbml-parameter"))) (define-module :class "kin-2-1_0_k1f_k1b" :super-classes ("s-2-1" "kinetics") :variables (("k1b" :is-a "kinetic-parameter") ("k1f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_k2f_k2b" :super-classes ("s-1-1" "kinetics") :variables (("k2b" :is-a "kinetic-parameter") ("k2f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_k3f_k3b" :super-classes ("s-1-1" "kinetics") :variables (("k3b" :is-a "kinetic-parameter") ("k3f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_v4_k4" :super-classes ("s-1-1" "kinetics") :variables (("k4" :is-a "kinetic-parameter") ("v4" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k5f_k5b" :super-classes ("s-2-1" "kinetics") :variables (("k5b" :is-a "kinetic-parameter") ("k5f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_k6f_k6b" :super-classes ("s-1-1" "kinetics") :variables (("k6b" :is-a "kinetic-parameter") ("k6f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_k7f_k7b" :super-classes ("s-1-2" "kinetics") :variables (("k7b" :is-a "kinetic-parameter") ("k7f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_v8_k8" :super-classes ("s-1-1" "kinetics") :variables (("k8" :is-a "kinetic-parameter") ("v8" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k9f_k9b" :super-classes ("s-2-1" "kinetics") :variables (("k9b" :is-a "kinetic-parameter") ("k9f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k10f_k10b" :super-classes ("s-2-1" "kinetics") :variables (("k10b" :is-a "kinetic-parameter") ("k10f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_k11f_k11b" :super-classes ("s-1-2" "kinetics") :variables (("k11b" :is-a "kinetic-parameter") ("k11f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_k12f_k12b" :super-classes ("s-1-2" "kinetics") :variables (("k12b" :is-a "kinetic-parameter") ("k12f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k13f_k13b" :super-classes ("s-2-1" "kinetics") :variables (("k13b" :is-a "kinetic-parameter") ("k13f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_k14f_k14b" :super-classes ("s-1-1" "kinetics") :variables (("k14b" :is-a "kinetic-parameter") ("k14f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_k15f_k15b" :super-classes ("s-1-2" "kinetics") :variables (("k15b" :is-a "kinetic-parameter") ("k15f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_v16_k16" :super-classes ("s-1-1" "kinetics") :variables (("k16" :is-a "kinetic-parameter") ("v16" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k17f_k17b" :super-classes ("s-2-1" "kinetics") :variables (("k17b" :is-a "kinetic-parameter") ("k17f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_k18f_k18b" :super-classes ("s-1-2" "kinetics") :variables (("k18b" :is-a "kinetic-parameter") ("k18f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k19f_k19b" :super-classes ("s-2-1" "kinetics") :variables (("k19b" :is-a "kinetic-parameter") ("k19f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_k20f_k20b" :super-classes ("s-1-2" "kinetics") :variables (("k20b" :is-a "kinetic-parameter") ("k20f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k21f_k21b" :super-classes ("s-2-1" "kinetics") :variables (("k21b" :is-a "kinetic-parameter") ("k21f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k22f_k22b" :super-classes ("s-2-1" "kinetics") :variables (("k22b" :is-a "kinetic-parameter") ("k22f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-2_0_k23f_k23b" :super-classes ("s-1-2" "kinetics") :variables (("k23b" :is-a "kinetic-parameter") ("k23f" :is-a "kinetic-parameter"))) (define-module :class "kin-2-1_0_k24f_k24b" :super-classes ("s-2-1" "kinetics") :variables (("k24b" :is-a "kinetic-parameter") ("k24f" :is-a "kinetic-parameter"))) (define-module :class "kin-1-1_0_k25f_k25b" :super-classes ("s-1-1" "kinetics") :variables (("k25b" :is-a "kinetic-parameter") ("k25f" :is-a "kinetic-parameter"))) (define-module :class "comparison-insulin-egf" :super-classes ("sbml-model") :geometry-width "468" :geometry-height "270" :modules (("insulin_reduced2_xml" :is-a "insulin_reduced2_xml" :geometry-x "323" :geometry-y "148") ("kholodenko1999_egfrsignaling" :is-a "kholodenko1999_egfrsignaling" :geometry-x "80" :geometry-y "154")))